Discuss the contribution of whole genome sequencing to the design and construction of “synthetic” organisms such as Syn 3.0 or Yeast 2.0. (10 marks) Explain how synthetic organisms could be used to improve the functional annotation of “wild” genomes.
Why do mammalian genomes have millions of repetitive Deoxyribonucleic acid elements that originate from transposable elements whereas bacteria have relatively few?
Compare and contrast the definitions of a gene as a unit of function versus a unit of heredity. When are these definitions in conflict and when are they in harmony?
Discuss the results of the Colony Insert Specific PCR products. Create table{s} to present the Insert PCR & RFLP results [see example below]. Determine the fragment size of each band on the gel.
Describe the structural features of a beta sheet. Can these secondary structural elements form between separate polypeptide chains? Justify your answer at a biochemical level.
Why does the immune system not recognize normal flora of microbes as antigens?
Describe the history of cell culture studies and consider; how they relate to normal physiology. Discuss how to have these help our understanding of hematopoietic activities.
Briefly describe the causes and initial pathophysiology of diabetes type II.
What is the significance of the portal venous system between the hypothalamus and anterior pituitary gland (known as the hypophyseal portal system)? What is the relationship between these two brain structures in terms of flow and direction of communication?
Explain why the cardiac-specific isoenzyme of creatine kinase (CK-MB) and cardiac-specific troponins are found in increased concentration within the plasma during acute myocardial infarction
