Concerning Pathophysiology related to admitting diagnosis

Concerning Pathophysiology related to admitting diagnosis and/or current problem, what would be the etiology, hypothetical progression, pathophysiology, and impact of age and gender on incidence and prevalence for the patient below?

 

Patient information:  presented to the ED with multiple complaints of pain and generalized malaise. Since Monday he has had multiple problems including chest pain, and shortness of breath. His abdomen and back have an achey pain (10/10), though he says if his sugar is under control its better but he can’t stand up. L side chest pain started Monday too, sharp in nature, deep breath make it worse. No recent trauma. Last BM daily. Headache frontal times 3 days. Chronic blurry vision from cataracts. He is lightheaded on standing up but otherwise no dizziness. No nausea, vomiting, dysuria, cough, pain with chewing or coughing. Walks with a cane. No heart attacks or stents. Takes meds as prescribed. Has urinary frequency sometimes with urgency. Has history of diabetes, hypertension, cataracts, and anemia.

Age: 60s

Gender: Male

Marital Status: Single

Support system: Children and family members.

Reason for for seeking care from patient’s own words: “Pain all over”

Admitting Medical Diagnosis: Acute Pericarditis

Vital Signs: 

BP is 168/86 on left arm while patient was sitting. Pulse is 75 bpm, Respirations is 18bpm, Height is 5’9″, Weight is 306 pounds, SPO2 94% ; BMI is 45.19 kg/m^2

Cardiovascular: regular rhythm, tachycardia present, no murmurs heard during heart sounds, no friction rub, no gallop

Peripheral Vascular:  warm/ well-perfused, no edema, no joint warmth or erythema.

Respiratory:  thorax was symmetric and equal in rage during chest expansion. Lungs are clear bilaterally. No adventitious sounds.

Pain: patient with acute onset left sided sharp chest pain with diffuse ST elevations. No stemi, troponin negative. Pain worsens w/deep inspiration and sharp all more consistent with pericarditis than ischemia.

Abdominal: Bowel sounds are normal. Abdomen is soft and there is no mass during palpations. Abdominal tenderness (mild discomfort to palpation diffusely). There is no guarding.

Skin: is dry and warm, normal turgor. Findings: rash (macular, erythematous rash to the LLQ of the abdomen with in punctuate skin break at right border. No tenderness, purulence, or fluctuance present.

Neuro:  no acute motor or sensory deficits, alert and oriented to person , place, time, CNII-XII grossly intact. Transxemic attack- occlusion caused symptoms

GU:  positive for difficulty urinating. Negative for dysuria.

Abdomen/GI:   positive for abdominal pain and constipation, negative for nauseas and vomiting.

Lines:   Left peripheral IV on AC 2g

Lab values during admission:  WBC 10.3, HGB: 9.5, Platelet 115, Sodium 138, Potassium 3.6, Chloride 104, CO2 26, BUN 33, Creatinine 1.39, Calcium 8.8, Glucose 209, Hematocrit 31.1

Electrocardiogram during admission:  reveals abnormal sinus rhythm rate 101 with diffuse ST elevations in all leads. No ST depressions or t-wave inversions.

Lab values day after admission:  WBC 10.4, HGB 9.3, Platelet 115, Sodium, 136, Potassium 3.6, Chloride 104, CO2 24,  BUN 33, Creatinine 1.35, Calcium 8.6, Glucose 224, Hematocrit 30.1

Radiology during admission:  XR Chest 1 VW. Findings: There is no evidence for consolidative infiltrate, pneumothorax, or pleural effusion. Cardiomegaly is demonstrated with a stable residual prominence of the central pulmonary vasculature. No acute abnormalities are seen. Impressions: no acute cardiopulmonary process demonstrated.

Transthoracic Echo (TTE) day after admission:  Findings were normal

 

Medications: 

albuterol 2.5 mg, inhalation, TID

allopurinol, 100 mg, oral, BID

aspirin delayed release, 81 mg, oral, daily with breakfast

Atorvastatin, 20 mg, oral, bedtime

carvedilol, 3.125 mg, oral, BID with meals

colchicine, 0.6 mg, oral, BID

enoxaparin, 40 mg, subcutaneous, q12h SCH

ferrous sulfate, 1 tablet, oral, Daily with breakfast

hydrochlorothiazide, 12.5mg, oral daily

Indomethacin, 50 mg, oral, TID with meals

insulin regular, 3 units, subcutaneous, TID

losartan, 100mg, oral, daily

nifedipine XL, 30 mg, oral , daily

polyethylene glycol, 17 g, oral, daily

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The diagnosis for this patient is Trichomoniasis. What are your two differential diagnoses?

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Physical Exam:

Vital signs:

  • Temperature is 36.8 C (98.3 F)
  • Pulse is 80 beats/minute
  • Respiratory rate is 14 breaths/minute
  • Blood pressure is 128/76 mmHg
  • Weight is 58.3 kg (128 lbs)
  • Height is 160 cm (63 in)
  • General: Well-developed, well-nourished, young female adult in no acute distress. Four-year-old son is in the room with her; patient is in the examination gown; she moves to sit on the table for the exam.
  • Pain: 3/10 (abdomen)
  • Neck: Supple, no bruits, lymphadenopathy, or thyromegaly.
  • Lungs: Clear to percussion and auscultation.
  • Heart: Regular rate and rhythm, no murmurs, rubs, gallops, or ectopy.
  • Abdomen: Bowel sounds positive in all quadrants. Mid-epigastric area nontender; bilateral lower abdominal tenderness to palpation. Some areas of ecchymosis present, across mid and lower abdomen in varying shades—purple to blue, yellow, and green. No masses or organomegaly; no rebound tenderness or guarding, although she does flinch at initial touch.
  • Back: No costovertebral tenderness or spine tenderness.
  • Pelvic Exam: External genitalia normal without lesions; small amount of yellowish discharge with mild malodor in vagina. Cervix parous without obvious discharge; No cervical motion tenderness. Uterus is possibly borderline enlarged, without palpable masses or significant tenderness. Adnexae slightly tender to palpation bilaterally; ovaries palpated, no masses noted.
  • Rectal exam: No masses; normal brown stool, negative hemoccult.
  • Neurological: Normal gait and speech; deep tendon reflexes (DTRs) 2+ and equal.
  • Extremities: No deformities, pulses 2+ and equal, ecchymoses on upper thighs and extensor aspects of forearms.
  • Skin: No rashes; bruises as noted, from purple to bluish to green to yellow, in various stages of resolution.

Summary statement:

Ms. Bell is a 28-year-old female who presents with lower abdominal pain for two weeks: achy pelvic pain worsened by activity and sexual intercourse. She reports associated nausea, vomiting, and alternating loose stools and constipation. Her last menstrual period was four weeks ago; she is sexually active without birth control and has many psychosocial stressors and reports her husband drinks alcohol frequently but she rarely drinks. Physical examination is notable for lower abdominal tenderness, numerous ecchymoses across her abdomen and extremities, a small amount of yellowish, malodorous vaginal discharge, and no cervical motion tenderness.