What is Diabetes Insipidus?

What is Diabetes Insipidus? ADH is produced in the hypothalamus and stored in the posterior pituitary gland
Its release is affected by serum osmolarity (you should know what that is—it is the amount of solute in relation to the fluid in the bloodstream)
When serum osmolarity is high (there are a lot of solutes in relation to the water—imagine ingesting a very salty meal), ADH is released and causes the kidneys to reabsorb water (to dilute that excess solute) and restore the serum osmolarity to normal.

This results in decreased urine output (because more water is being retained) and the urine is more concentrated and has a higher specific gravity/urine osmolarity

Some people do not make ADH or it does not work.

This causes DI/Diabetes insipidus, which means excessive urine output.

If the cause is a lack of ADH, it can be replaced with an ADH replacement known as desmopressin.  Review how it is used and major adverse effects/teaching

Thyroid gland
Please review the actions and effects of thyroid hormone on the body—you must understand what this hormone made by the body does to understand the effect of too much or too little on the body
What lab work is done to diagnose problems with the thyroid gland?

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