A 65-year-old female comes to the clinic with a complaint of abdominal pain in the epigastric area. The
pain has been persistent for two weeks. The pain described as burning, non-radiating and worse after
meals. Denies N&V, weight loss or obvious bleeding. She admits to frequent belching with bloating.
PMH: seasonal allergies with Chronic Sinusitis, positive for osteoarthritis,
Meds: Claritin 10 mg po daily, ibuprofen 400-600 mg po prn pain
Family Hx-non contributary
Social history: Separated recently pending divorce; stressful situation with trying to manage two homes.
Works as a Legal Assistant at a local law firm. She has 35 PPY of smoking, drinks 1-2 glasses of wine a
day, and 6-7 cups of coffee per day. She denies illicit drug use, vaping or unprotected sexual
Breath test in the office revealed + urease.
The healthcare provider suspects the client has peptic ulcer disease.
1. What is the pathophysiology of PUD/ formation of peptic ulcers?