Blood dotting in humans and its loss causes hemophilia

Factor VII is a protein that is crucial for blood dotting in humans and its loss causes hemophilia. A DNA done in a mammalian expression vector was introduced into a fertilized cow us to generate a transgenic cow. The goal is to express the protein in milk and then purify it. What considerations should be taken to implement this idea successfully! a. Use a skin-specific constitutive promoter. b. Use a strong promoter like the trp. Use a mammary gland-specific promoter and secretion signal peptide. Use a poly(A) tail promoter.