Bubble Syndrome affects adenosine deaminase and leads to

Bubble Syndrome affects adenosine deaminase and leads to immunodeficiency and thus susceptibility to infections. The reduction of immune cells may be associated with inhibition of: Hypoxanthine guanine phosphoribosyltransferase Ribonucleotide reductase Adenine phosphoribosyltransferase purine nucleoside phosphorylase