The leading cause of morbidity and mortality in the US is cardiovascular disease

The leading cause of morbidity and mortality in the US is cardiovascular disease. It is commonly a result of years of chronic inflammatory changes to the lining of the blood vessel (endothelium) caused by excessive calories (free radical oxygens from burning fats) and lack of exercise (insulin resistance) and/or smoking. Metabolic syndrome is a constellation of excessive central fat (waist>hip ratio) high blood pressure + elevated LDL with low HDL + insulin resistance (pre-diabetes) or Type 2 diabetes. We use medications in combinations to reduce LDL cholesterol, reduce triglycerides, reduce weight, lower blood pressure, improve insulin resistance, and lower blood sugar levels.

Choose one drug from each of these categories and discuss how they work together better than they would work separately. You will need to demonstrate an understanding of how they interact on the body (pharmacodynamics).

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