Clostridium difficile-associated diarrhea

Which of the listed antibiotics is most prone to cause the serious side effect of Clostridium difficile-associated diarrhea?     Question options:  A)   Cephalexin (Keflex)   B)   Ciprofloxacin (Cipro)   C)   Minocycline (Minocin)   D)   Azithromycin (Zithromax)   E)   Trimethoprim- sulfamethoxazole (Bactrim)