Discuss the concept of genomic imprinting and parent-of-origin effects on gene expression and phenotype

Discuss the concept of genomic imprinting and parent-of-origin effects on gene expression and phenotype. Explain how epigenetic modifications, such as DNA methylation, regulate gene expression in an allele-specific manner, leading to differential expression of imprinted genes based on their parental origin. Explore the implications of genomic imprinting for development, behavior, and disease susceptibility in mammals.