The consequences of dysregulated bone remodeling on skeletal health

Describe the physiological mechanisms underlying the regulation of bone remodeling and mineral homeostasis, including the roles of osteoblasts, osteoclasts, and hormonal factors such as parathyroid hormone (PTH) and calcitonin. How do osteoblasts synthesize and mineralize bone matrix, while osteoclasts resorb bone tissue to maintain skeletal integrity and regulate calcium and phosphate levels in the blood? Additionally, how does PTH stimulate bone resorption and increase calcium reabsorption in the kidneys and intestines, thereby raising serum calcium levels and promoting bone turnover? Furthermore, how does calcitonin inhibit osteoclast activity and decrease bone resorption in response to hypercalcemia, and what are the consequences of dysregulated bone remodeling on skeletal health and bone density?