Epinephrine toxicity

All the following statements related to epinephrine toxicity are correct EXCEPT which one? A. Epinephrine has a relatively narrow therapeutic window, reaching peak plasma levels in 5-10 minutes. B. Since epinephrine crosses the blood-brain barrier, epinephrine-associated ADRs are the result of CNS effects. C. Signs and symptoms of epinephrine toxicity include restlessness, agitation, anxiety, tremulousness, headache, dizziness, pallor, palpitation, and tachycardia. D. In patients with Parkinson’s disease, epinephrine may increase tremor and rigidity.