Progressively Worsening knee pain

Aleli is a 50-year-old avid marathon runner who is being seen in the local pharmacy quick clinic for progressively worsening knee pain over the last year. She reports that her knee pain is worse in the morning. She has been continuing to run a few days a week but is not running any long distances.

She has been using acetaminophen (Tylenol^®), but it is no longer relieving her pain.

Aleli takes no other medications. She drinks red wine at night for dinner or social events, and she does not have any smoking history. Her family has a history of heart disease; her father died of a sudden heart attack when he was 50 years old. She also has a family history of arthritis and colorectal cancer.

She is prescribed ibuprofen 800 mg twice a day to use for knee pain and to follow up with a primary care provider as needed.

Discuss the use of ibuprofen for this Aleli.