The Treatment of seizures

An 8-year-old, 25- kg male, is receiving a 250−mg capsule of valproic acid (VA) q12h for the treatment of seizures. – The Cls of VA are 13 mL/kg/h for children and 8 mL/kg/h for adults. The V and F of VA are 0.14 L/kg and 1, respectively. The therapeutic plasma VA concentrations are 50-100 mg/L. The toxicity is observed as >200mg/L. WS has normal hepatic

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