Types of epilepsy and the mechanisms that cause seizure

You are studying different types of epilepsy and the mechanisms that cause seizure activity. While researching, you find that it’s usually caused by a mutation in different types of sodium channels. Please answer the following prompts.

 

  1. The first mutation causes voltage-gated sodium channels to recover from inactivation faster. How would this impact action potentials and firing rate? If this mutation causes seizures, would these channels be found on GABAergic or glutamatergic neurons? Explain.
  2. The other mutation causes voltage-gated sodium channels to open at a more positive membrane potential. How would this impact action potentials and firing rate? If this mutation causes seizures, would these channels be found on GABAergic or glutamatergic neurons? Explain.

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