The pathophysiology of DMII

The nurse understands the pathophysiology of DMII and the agents that are available to patients, and Match the drug class with the correct description. sitagliptin-Dipeptidyl peptidase 4 Inhibitors A. MOA- Simulate release of insulin from beta cells of the pancreas and diminish glucose production and metabolism of insulin by the liver. In general, this medication should not be given to patients with a Sulfa allergy. Dulaglutide/Glucagon- Like Peptide-1 Agonist B. MOA – works with the incretin hormones (prolonging their beneficial effects by inhibiting rapid metabolism) which reduces hyperglycemia. Can be used as an adjunct or monotherapy.

One positive benefit is that it will enhance insulin secretion only in the presence of hyperglycemia (making hypoglycemia less of a risk, especially If used as a monotherapy). v canagliflozin C. MOA – SGLT2 reabsorbs glucose back Into the circulation via the glomerulus. In Type II DM SGL2 is oversecreted, therefore (gliflozins )/Sodium- aggravating hyperglycemia. Inhibitors to SGLT2 will allow more glucose to be excreted (in the urine). Can be used as mono Glucose Cotransporter 2 therapy. Counsel patients regarding the risk for UTI. Inhibitors (SGLT2) Acarbose/Alpha- D. MOA – Increases insulin sensitivity and reduces hepatic gluconeogenesis.

Though not Indicated as initial therapy for DM II, Glucosidase Inhibitor can be a monotherapy. May take 4-6 weeks for full therapeutic effects. Contraindicated with severe heart failure. agents – Rosiglitazone/Thiazolidin E. MOA – Enhances insulin secretion only in the presence of hyperglycemia, Is not a monotherapy Is an injection. edition (TZDs) – Repaglinide/Meglitinides F. MOA- Increases insulin sensitivity, reduces the absorption of glucose in the small intestine, and reduces hepatic glucose production. Can be used as a monotherapy and does not cause weight gain, and may have a favorable effect on lipids. Must have an adequate glomerular filtration rate, and special care is taken to protect kidneys if radiopaque IV dyes are needed for imaging diagnostics. – > Glipizide/Sulfonylurea G. MOA-Stimulate the release of insulin from beta cells of the pancreas. Can be used as a monotherapy. The short duration of action requires frequent dosing (risk of compliance). Given preprandial, and dose should be held if meals are skipped. – Metformin/Biguanides H. MOA-Inhibits enzymes used in the digestion of sugars, delaying glucose absorption with meals, thus lowering postprandial hypoglycemia. If used as a monotherapy, makes hypoglycemia is very unlikely, but if occurs must use dextrose, not sucrose (table sugar) to treat it.

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Using the OARS strategy for communication

Using the OARS strategy for communication, Write 3 open-ended questions, 3 affirmations, and 1 reflection statement for each scenario below:

Scenarios for round 2:

1. Resident has just moved to long-term-care. He is mentally intact but has been weak and falling at home. His children live far away and have just left after moving him to the facility. He says that he wants to go home but knows it isn’t safe. He is angry at himself and his children for making him leave his home of 40 years.

2. You are speaking with a patient who has MS. He was admitted to your SNF after a fall and feels hopeless. He knows this is a lifelong condition that will eventually end in death. He is 55 and had been in good health. He says he is depressed and wants to just die and get it over with.

3. (No resident role. Switch to co-worker role) You have a coworker who is constantly bossing and berating the younger and less experienced staff around. They have told you they are scared of this coworker and want to quit. You and the coworker are in the breakroom and you want to talk about this with her to see if she will change her behavior.

The types of skin grafts

Compare and contrast the meanings of word elements that describe the types of skin grafts. Fill in the blank with the correct term. LO 4.6, 4.7 1. A graft from another species is a xenograft and a 2. A graft from another person is an allograft and a 3. A graft is taken from one part of a person’s body and placed elsewhere on the same body:

Conflict-management techniques

What Are Some Techniques for Handling Difficult People? Now that we have discussed conflict-management techniques, we are ready to look at techniques for handling difficult people. How do you deal with an abusive physician or supervisor? How do you react when someone constantly complains and grips about something? How do you handle the know-it-all who will not even listen to your thoughts about an issue? Implications for Nursing Practice Effective role socialization occurs when the nurse engages in actions that benefit other nurses and/ or patients and families by helping, supporting, and encouraging mutual goal accomplishment and/ or well-being.

There must be positive interdependence among the nursing staff. • Nurses must understand and use constructive conflict-management skills. • Mediation techniques should be employed when disputes arise between employees and/ or patients and their families. • There must be a high level of trust among the nursing staff. • Prosocial behavior should be noted among staff, with the feeling of “sink or swim together” versus “you sink and I swim.” • Do not procrastinate in dealing with difficult employees, patients, or their families. • A high basic self-esteem is noted among nursing staff in an empowering, healthy workplace environment. • The conflict negotiation strategy used may be collaboration (win-win) or mediation. Considering this Information How might you use some of the strategies listed in this chapter to handle a difficult employee? What types of activities are you involved in as a student that promote a positive professional practice environment? What essential skills would be important for a nurse to possess to serve as a mediator?

The evaluation phase of the nursing process

The nurse is administering a medication noted to be vicious. What additional step must be added? 0 Insert the needle at a 90-degree angle 0 Pull the skin laterally 0 Immediately remove the needle after the injection is complete. 0 Pull the skin taut What action best matches the evaluation phase of the nursing process? 0 Counting the apical pulse before giving a dose of the medication 0 Counting the apical pulse and checking the blood pressure after giving the dose of medication 0 Identifying " Decreased Cardiac Output" as a client problem, 0 Teaching the client about their cardiac medication 0 Developing an outcome that the heart rate will be between 60—100 after giving the medication A client is prescribed 500mg of acetaminophen, PO, once. How much medication will remain in the client’s body at 4 half-lives? (Enter your answer to the nearest hundredth decimal place).

The profiled elephant’s genotype

The elephant profiled here is heterozygous for the FH67 marker; it has two different alleles for this marker with relative frequencies of 0.1 and 0.24. Based on the formula in Question 7, the probability of an elephant from this population having the profiled elephant’s genotype for the FH67 marker is 2(0.1)(0.24) = 0.048. What is the probability of an elephant from this population having the profiled elephant’s genotype for the F127 marker? Show your work.

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Discovery and biopharmaceutical product development process

Given the discussion in the article (link is below), please opine on how the drug discovery and biopharmaceutical product development process can be improved to better support evaluations of safety and efficacy for these products.

For example, should the approved indication(s) for use for new biomedical products be constrained to specific populations in which genetic analysis has been thoroughly analyzed as part of the clinical development process? Should all pivotal Phase III clinical trials be limited in scope with respect to the genetic composition of patients included within the study? Please justify your responses with examples from the article (link) below.

What is a statistical definition of abnormality?

1) Sexual Addiction: What qualifies something as a sexual addiction?

  • Can you think of a behavior that you would qualify as a paraphilia that does not qualify as a sexual addiction? On which qualification does it escape the label of addiction? Do you think sex addiction is an adequate explanation for paraphilic behavior?

2) Determining Abnormality: What is a statistical definition of abnormality? How do sociological, psychological, and medical approaches to abnormality differ from the statistical definition?

  • Which do you think is the proper approach to use?
  • How would each approach evaluate a person who watches soft-core pornography on a daily basis?

The key component of health-related physical fitness

Cardiorespiratory endurance is often considered the key component of health-related physical fitness. Why is this the case? How can cardiorespiratory endurance be measured and how can it be improved? What activities, if any, do you participate in that are geared toward improving cardiorespiratory endurance? How does this kind of physical activity/exercise make you feel? Offer some suggestions for maintaining motivation to engage in activities that improve cardiorespiratory endurance.

 Describe the importance of Play on a child’s overall development

Describe the importance of Play on a child’s overall development. How do they play and the skills learned during play affect each area of development (language, cognition, psychosocial, motor, adaptive, social skills, and sensory). What would you tell a parent about the importance of play and how it is a child’s “occupation”