The coronary artery calcification

Which of the following best summarizes the research on long-term endurance exercise?
Research shows that in terms of the health benefits of exercise, more is always better in terms of the overall protective effect.
There are potential health risks including coronary artery calcification, a risk factor for cardiovascular disease
There is a dose-response relationship between the number of hours per week engaged in endurance exercise and cardiovascular benefits
There is a dose-response relationship between the number of hours per week engaged in endurance exercise and the mental health benefits

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