Which drugs are included in First-line therapy?

Which drugs are included in first-line therapy?. Would directly observed therapy be appropriate for this patient? Why or why not?. What are the teaching priorities for this patient?

The patient is a 48-year-old man who is being released from prison after 15 years of incarceration. On his final
physical, he is found to be 20 pounds underweight for his height and has a productive cough. He smokes three packs
of cigarettes daily and is exposed to a great deal of secondhand smoke in the prison environment. On release, he is
going to live with his 70-year-old aunt. A tuberculin skin test injected 3 days ago shows a 12 mm area of induration
around the injection site. His records indicate that his last skin test, performed 18 months ago, did not result in any
reaction. After other tests confirm that he has active TB, he is started on first-line anti-tuberculosis therapy drugs.