Human immunodeficiency virus (HIV)

Summarize the human immunodeficiency virus (HIV) in terms of etiology, pathogenesis, clinical picture, diagnosis, and treatment rationale.

 

The 5 General Topics of Disease Summary
1. Etiology & risk factors
2. Pathogenesis: The molecular mechanism of the disease process (How the disease process evolves)
3. Clinical Picture: Signs& Symptoms, Sequelae, and Complications
4. Diagnosis: Labs & tests (as well as screening tests and follow up tests whenever applicable)
5. Pathophysiologic rationale of treatment

 

  1. Etiology: Type of the causative virus and its characteristics. Mode of transmission.

 

  1. Pathogenesis: Which cell is infected by the virus (The CD-4 cell), and what are the steps the virus takes to infect this cell and reproduce inside (1. entry, 2. reverse-transcription, 3. Integration, 4. Assembly and release). The sequelae of infecting the CD-4 cells and how this affects the immune system.

 

  1. Clinical Picture: of HIV infection and the clinical picture of AIDS

 

  1. Diagnosis: Diagnostics to diagnose HIV, diagnose AIDS, and follow up the condition and prognosis.

 

  1. The pathophysiologic rationale of treatment: examples of drugs working at each of the 4 steps the virus takes to infect the CD-4 cell.

This is the textbook for information:

McCance, K.L., Huether, S. E. (2018) Pathophysiology: The Biological Basis for Disease in Adults and Children. (8th Ed) St. Louis, MO. Elsevier Mosby ISBN-13: 978-0323583473 ISBN-10: 9780323583473

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