A 52-year-old obese Caucasian male presents to the clinic with a 2-day history of fever, chills, and right great toe pain that has gotten worse. The patient states this is the first time that this has happened, and nothing has made it better, and walking on his right foot makes it worse. He has tried acetaminophen, but it did not help. He took several ibuprofen tablets last night which did give him a bit of relief. Past medical history positive or hypertension treated with hydrochlorothiazide and kidney stones. Social history negative for tobacco use but admits to drinking “a fair amount of red wine” every week. General appearance: Ill-appearing male who sits with his right foot elevated. A physical exam is remarkable for a temp of 101.2, the pulse of 108, respiration of 18, and BP of 160/88. The right great toe (first metatarsal phalangeal [MTP]) is noticeably swollen and red. Unable to palpate to assess a range of motion due to extreme pain. CBC and Complete metabolic profile revealed WBC 14,000 mm3 and uric acid 8.9 mg/dl. The APRN diagnoses the patient with acute gout.
Question 1 of 2:
Describe the pathophysiology of gout.
Explain why a patient with gout is more likely to develop renal calculi.