WBCs Disorders: Leukemia and Lymphoma

Summarize the WBCs Disorders: Leukemia and Lymphoma in terms of etiology, pathogenesis, clinical picture, diagnosis, and treatment rationale.

Leukemia:

1. Etiology:

• Talk about the four main types of leukemia (AML, ALL, CML, CLL)
• Talk about the mutations involved in the etiology of leukemias.

2. Pathogenesis:

Talk about the steps that follow the mutations and lead to the development of leukemias and how they lead to anemia, platelet dysfunction, and infection.

3. Clinical Picture:

Common manifestations of leukemias in general (acute vs chronic). Blast crisis.

4. Diagnosis:

• CBC findings in leukemias, blast cells, Philadelphia chromosome of CML

5. The pathophysiologic rationale of treatment:

Talk about why we need to treat anemia, bleeding tendency and risk of infections in leukemia.

Lymphoma:

1. Etiology & Pathogenesis:

• Talk about the types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma

2. Clinical Picture:

Lymphoma A (Asymptomatic), Lymphoma B (Talk about the symptoms)

3. Diagnosis& Staging:

Talk about the 4 stages of lymphoma

4. The pathophysiologic rationale of treatment:

Talk about how staging determines the lines of therapy (especially radiation).

This is the textbook for information:

McCance, K.L., Huether, S. E. (2018) Pathophysiology: The Biological Basis for Disease in Adults and Children. (8th Ed) St. Louis, MO. Elsevier Mosby ISBN-13: 978-0323583473 ISBN-10: 9780323583473