WBCs Disorders: Leukemia and Lymphoma

Summarize the WBCs Disorders: Leukemia and Lymphoma in terms of etiology, pathogenesis, clinical picture, diagnosis, and treatment rationale.


The 5 General Topics of Disease Summary
1. Etiology & risk factors
2. Pathogenesis: The molecular mechanism of the disease process (How the disease process evolves)
3. Clinical Picture: Signs& Symptoms, Sequelae, and Complications
4. Diagnosis: Labs & tests (as well as screening tests and follow-up tests whenever applicable)
5. Pathophysiologic rationale of treatment



  1. Etiology:
  • Talk about the four main types of leukemia (AML, ALL, CML, CLL)
  • Talk about the mutations involved in the etiology of leukemias.
  1. Pathogenesis:

Talk about the steps that follow the mutations and lead to the development of leukemias and how they lead to anemia, platelet dysfunction, and infection.

  1. Clinical Picture:

Common manifestations of leukemias in general (acute vs chronic). Blast crisis.

  1. Diagnosis:
  • CBC findings in leukemias, blast cells, Philadelphia chromosome of CML
  1. The pathophysiologic rationale of treatment:

Talk about why we need to treat anemia, bleeding tendency and risk of infections in leukemia.



  1. Etiology & Pathogenesis:
  • Talk about the types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma
  1. Clinical Picture:

Lymphoma A (Asymptomatic), Lymphoma B (Talk about the symptoms)

  1. Diagnosis& Staging:

Talk about the 4 stages of lymphoma

  1. The pathophysiologic rationale of treatment:

Talk about how staging determines the lines of therapy (especially radiation).


This is the textbook for information:

McCance, K.L., Huether, S. E. (2018) Pathophysiology: The Biological Basis for Disease in Adults and Children. (8th Ed) St. Louis, MO. Elsevier Mosby ISBN-13: 978-0323583473 ISBN-10: 9780323583473

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