Bleeding and  thrombotic Disorders: platelet and coagulation disorders

Summarize the bleeding and thrombotic disorders: platelet and coagulation disorders in terms of etiology, pathogenesis, clinical picture, diagnosis, and treatment rationale.


The 5 General Topics of Disease Summary
1. Etiology & risk factors
2. Pathogenesis: The molecular mechanism of the disease process (How the disease process evolves)
3. Clinical Picture: Signs& Symptoms, Sequelae, and Complications
4. Diagnosis: Labs & tests (as well as screening tests and follow up tests whenever applicable)
5.Pathophysiologic rationale of treatment


Platelet Disorders: Talk about TWO DISORDERS: Low platelet count (Thrombocytopenia), increased platelet count (Thrombocytosis)

  • Thrombocytopenia:
  1. Etiology& Pathogenesis: different types of thrombocytopenia and what cause them, also talk about causes of defective platelet function including antiplatelet medication effects
  2. Clinical Picture: manifestations of low-platelet bleeding disorders. (in contrast to clotting factor deficiency bleeding disorder)
  3. Diagnosis: bleeding time, platelet count, Thromboelastography with platelet mapping.
  4. Pathophysiologic rationale of treatment: indications of platelet transfusion.
  • Thrombocytosis:
  1. Etiology& Pathogenesis: as a part of myeloproliferative disorder (essential thrombocytosis)
  2. Clinical Picture: Signs& Symptoms of thrombocytosis and complications
  3. Diagnosis:
  4. Pathophysiologic rational of treatment:



Coagulation Disorders: Talk about TWO DISORDERS: Hypocoagulability (Coagulopathy) and Hypercoagulability.

  • Hypocoagulability:
  1. Etiology& Pathogenesis: Acquired causes of bleeding tendency (other than genetic causes): including liver failure, uremia, vit K deficiency & warfarin overdose.
  2. Clinical Picture: manifestations of coagulopathy (in contrast to platelet disorder types of bleeding)
  3. Diagnosis: PT & PTT (how each can help diagnose extrinsic vs intrinsic pathway disorders)
  4. Pathophysiologic rationale of treatment:
  • Hypercoagulabilty:
  1. Etiology& pathogenesis: Factor V Leiden, Protein C deficiency, Protein S deficiency, antiphospholipid syndrome.
  2. Clinical Picture: Complications of hypercoagulability
  3. Diagnosis:
  4. The pathophysiologic rationale of treatment.


This is the textbook for information:

McCance, K.L., Huether, S. E. (2018) Pathophysiology: The Biological Basis for Disease in Adults and Children. (8th Ed) St. Louis, MO. Elsevier Mosby ISBN-13: 978-0323583473 ISBN-10: 9780323583473

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